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Director Tom Six stated in 2010 that he was working on a sequel to The Human Centipede (First Sequence), as well as a possible third film depending upon its success. He said that the plot would follow on from the first film, but with a centipede made from 12 people as opposed to the three victims of the first.
The second movie, "The Human Centipede 2 (Full Sequence)," follows a man who becomes obsessed with the first movie and decides to create his own human centipede.
Poker is a family of games that exhibit imperfect information, where players do not have full knowledge of past events. Whereas many perfect-information games have been solved (e.g., Connect Four and checkers), no nontrivial imperfect-information game played competitively by humans has previously been solved.
Pluribus's self-play produces a strategy for the entire game offline, which we refer to as the blueprint strategy. Then during actual play against opponents, Pluribus improves upon the blueprint strategy by searching for a better strategy in real time for the situations in which it finds itself during the game.